Study of nonlinear Poisson-Boltzmann equation for a rodlike macromolecule using the pseudo-spectral method
Abstract: The pseudo-spectral method with the Chebyshev and Legendre polynomials are used in order to compute the electric potential for a rodlike macromolecule located in salt free solution via the Poisson-Boltzmann equation (PBE). Afterwards, verification of the method is demonstrated for a long macromolecule as well as a large plate for which the behaviors can be properly explained by a one-dimensional PBE. It is concluded that the method based upon the Chebyshev polynomials with the specified collocation points is more accurate than the technique based on the Legendre polynomials with the same number of points. As a macromolecule has a rodlike shape, a two-dimensional PBE is considered, which corresponds to a much more realistic case. To solve the PBE, the concentration of the macromolecule in the solution and the electric field are used to compute the height and radius of the unit cell, which are obtained to be as 16.7 and 8.1 nm, respectively. It is worth noting that numerical computation of the PBE for a macromolecule with a finite length has not been reported previously using the pseudo-spectral method. The results given in this work can be appropriately used for stiff fragments of DNA and actin filaments.

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Shaghayegh Nikzad, Department of Energy Engineering and Physics, Amirkabir University of Technology (Tehran Polytechnic)

Houshyar Noshad, Department of Energy Engineering and Physics, Amirkabir University of Technology (Tehran Polytechnic)

Esmaeil Motevali, Department of Energy Engineering and Physics, Amirkabir University of Technology (Tehran Polytechnic)



Therapeutic impacts of microRNAs in breast cancer by their roles in regulating processes involved in this disease
Abstract : Breast cancer is the most common cancer in women around the world. So far, many attempts have been made to treat this disease, but few effective treatments have been discovered. In this work, we reviewed the related articles in the limited period of time, 2000–2016, through search in PubMed, Scopus database, Google Scholar, and psychology and psychiatry literature (PsycINFO). We selected the articles about the correlation of microRNAs (miRNAs) and breast cancer in the insight into therapeutic applicability from mentioned genetics research databases. The miRNAs as an effective therapy for breast cancer was at the center of our attention. Hormone therapy and chemotherapy are two major methods that are being used frequently in breast cancer treatment. In the search for an effective therapy for breast cancer, miRNAs suggest a promising method of treatment. miRNAs are small, noncoding RNAs that can turn genes on or off and can have critical roles in cancer treatment; therefore, in the near future, usage of these biological molecules in breast cancer treatment can be considered a weapon against most common cancer‑related concerns in women. Here, we discuss miRNAs and their roles in various aspects of breast cancer treatment to help find an alternative and effective way to treat
or even cure this preventable disease.

Authors : Amir Mehrgou, Mansoureh Akouchekian
Department of Medical Genetics and Molecular Biology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Improving the Surface Properties of Gray Cast Iron through In – Situ Alloying
Abstract :Conventionally, alloying elements are being added to the whole melt; however, in this research in-situ surface alloying of gray cast iron was employed to improve surface properties of the castings. Wires of pure copper with diameters of 0.4 and 0.8 mm were inserted and fixed at bottom of sand molds before melting. Chemical composition analysis revealed the presence of copper from surface to a depth of 1 cm. Microstructural investigations indicated that graphite type changed from A to D and E. Moreover, the content of graphite phase decreased while that of pearlite increased at the surface. Hardness was higher at surface of copper added samples. Wear resistant of the in-situ surface alloyed samples was better than the no-copper added ones.
M. Khoobroo , A. Maleki , B. Niroumand : Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran.
The effect of probiotic in treatment of infantile colic: A randomized clinical trial study

Background: Infantile colic imposes a heavy financial burden on families and the healthcare system. This study was conducted to evaluate the effect of Pedilact on the treatment of infantile colic. Materials and Methods: In this randomized clinical trial, 84 infant younger than 3 months with infantile colic were divided in two groups of 42 cases each- probiotic and standard treatment. This study was done in Arak city, Iran between 2013 and 2016. The population of the study consisted of breastfed infants and formula-fed infants younger than 3 months (less than 13 weeks) who referred to Amir Kabir Hospital and pediatric clinics presenting crying and restlessness symptoms consistent with the modified Wessel criteria. In the treatment group, in addition to the main treatment, five drops of Pedilact (Iran) was daily administered for 28 days. In both groups, the main treatment was instructed to the parents and they were advised to do the following techniques to pacify the infant: making relaxing sounds or vocals, applying peaceful and rhythmic rocking motion, walking, and using mild tremor-like movements. Results: In Pedilact and control groups, 54.75% and 28.57% of the cases were male, respectively. 23 infants (75.61%) in the Pedilact group and 33 infants (82.5%) in the control group were breastfed infants. The mean age of infants in Pedilact and control groups were 6.64 + 2.90 and 6.69 + 5.97, respectively. There was no significant difference between the Pedilact and control groups in terms of mean duration of crying time during a day (P= 0.075), and the number of crying attacks per day (P= 0.127), there was a significant decrease in both variables over time, but the mean for hours of sleep in the group receiving the standard treatment was significantly higher than that of the group receiving Pedilact (P= 0.001). Conclusion: There was no significant difference between the control and Pedilact groups in terms of crying time during a day and the number of crying attacks. It should be mentioned that, in this study, sample size was relatively low; hence, a multicenter study is recommended.


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Author : Fatemeh Dorreh 1, *Seyed Mojtaba Hashemi1, Sajedeh Salehi 1, Majid Taheri 2, Amir AlmasiHashiani 3 1

1Department of Pediatrics, Arak University of Medical Sciences, Arak, Iran. 2Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 3Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Thermostable chitinase from Cohnella sp. A01: isolation and product optimization
Abstract :
Twelve bacterial strains isolated from shrimp farming ponds were screened for their growth activity on chitin as the sole carbon source. The highly chitinolytic bacterial strain was detected by qualitative cup plate assay and tentatively identified to be Cohnella sp. A01 based on 16S rDNA sequencing and by matching the key morphological, physiological, and biochemical characteristics. The cultivation of Cohnella sp. A01 in the suitable liquid medium resulted in the production of high levels of enzyme. The colloidal chitin, peptone, and K2HPO4 represented the best carbon, nitrogen, and phosphorus sources, respectively. Enzyme production by Cohnella sp. A01 was optimized by the Taguchi method. Our results demonstrated that inoculation amount and temperature of incubation were the most significant factors influencing chitinase production. From the tested values, the best pH/temperature was obtained at pH 5 and 70°C, with Km and Vmax values of chitinase to be 5.6mg/mL and 0.87μmol/min, respectively. Ag+, Co2+, iodoacetamide, and iodoacetic acid inhibited the enzyme activity, whereas Mn2+, Cu2+, Tweens (20 and 80), Triton X-100, and EDTA increased the same. In addition, the study of the morphological alteration of chitin treated by enzyme by SEM revealed cracks and pores on the chitin surface, indicating a potential application of this enzyme in several industries.



Nasrin Aliabadi – Shiraz University of Medical Sciences
Saeed Aminzadeh – National Institute of Genetic Engineering and Biotechnology
Ali Asghar Karkhane – National Institute of Genetic Engineering and Biotechnology
Kamahldin Haghbeen – National Institute of Genetic Engineering and Biotechnology


Shiraz Second International Congress on Mobile Health

Mobile Health or mHealth,as a sub-segment of eHealth,is a term used for the practice of medicine and public health supported by mobile devices.The main goal of the congress is to provide a vehicle for exchanging ideas,concepts,techniques,experiments and applications in using mobile communication devices,such as mobile phones,tablet computers and handheld PCs,for health services and information.Shiraz International mHealth congress-2017 mainly focuses on the delivery of healthcare services via mobile communication and multimedia technologies.Authors are kindly requested to submit their abstract via the website of the congress. Accepted abstracts will be published on the congress official website and in the supplement of the Shiraz E-Medical Journal (this journal is currently indexed/abstracted in some major indexing systems such as Scopus.).


Congress to be held on :  February 22-23 2017
Address: Shiraz Information Technology Incubator of Medical Sciences – Next to Sina & Sadra Convention Halls – Neshat street – Shiraz – Iran
Strategies of Hepatitis B vaccine export

Strategies of Hepatitis B vaccine export to the Middle East and Central Asian countries. This paper proposes an appropriate strategy for exporting Hepatitis B vaccine, manufactured by Pasteur Institute of Iran, to other countries. Methods: Eeffectiveness factors and their relative variables were found out by factor analysis method in SPSS software. Results: We could identify 6 main factors which can extremely affect the export of this product. We evaluated manufacturer’s strategic position among its competitors and the production market via SPACE model and put the obtained scores from the factor analysis method in this model matrix. Conclusion: We determined Iraq as the target market and identified suitable strategies for exporting the vaccine to this country.

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Written by : MR Maleki, Y Diba

Master of Business Administrative – Najafaabad Campus of Islamic Azad University